Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29740522 | 0.84 | TDP1 (0.56) | TDP1POLBLMNAALDH1A1KDM4E | |
| SCHEMBL5277177 | 0.84 | TDP1 (0.56) | TDP1POLBLMNAALDH1A1KDM4E | |
| SCHEMBL11534866 | 0.84 | TDP1 (0.56) | TDP1POLBLMNAALDH1A1KDM4E | |
| SCHEMBL19588472 | 0.83 | TDP1 (0.62) | TDP1POLBLMNAALDH1A1KDM4E | |
| SCHEMBL30423475 | 0.83 | TDP1 (0.54) | TDP1POLBLMNAALDH1A1L3MBTL1 | |
| SCHEMBL29257418 | 0.83 | TDP1 (0.54) | TDP1POLBLMNAALDH1A1L3MBTL1 | |
| SCHEMBL7395617 | 0.83 | TDP1 (0.54) | TDP1POLBLMNAALDH1A1KDM4E | |
| SCHEMBL8732975 | 0.81 | TDP1 (0.61) | TDP1POLBLMNAALDH1A1KDM4E | |
| SCHEMBL13455143 | 0.81 | TDP1 (0.53) | TDP1POLBLMNAALDH1A1KDM4E | |
| SCHEMBL5274914 | 0.81 | TDP1 (0.53) | TDP1POLBLMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4167638-A | Process for production of 8-NHR quinolines | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1979-09-11 | — | — | US | claimed |
| US-4431807-A | PARASITICIDES; MALARIA; TISSUE AND BLOOD DISORDERS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1984-02-14 | — | — | US | disclosed |
| US-4167638-A | Process for production of 8-NHR quinolines | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1979-09-11 | — | — | US | disclosed |