SCHEMBL11075835

SCHEMBL11075835

CC(=O)Nc1ccc(S(=O)(=O)N2CCN(c3ccccc3OC[C@@H]3CO[C@@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)CC2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 19/20 0.57
LMNA P02545 2/20 0.54
FYN P06241 2/20 0.54
CYP51A1 Q16850 2/20 0.54
NR1I2 O75469 1/20 0.54
PGR P06401 1/20 0.54
HSP90AA1 P07900 1/20 0.54
CHRM2 P08172 1/20 0.54
CHRM4 P08173 1/20 0.54
CHRM5 P08912 1/20 0.54
ADRA2A P08913 1/20 0.54
CHRM1 P11229 1/20 0.54
TSHR P16473 1/20 0.54
ADRA2B P18089 1/20 0.54
ADRA2C P18825 1/20 0.54
CHRM3 P20309 1/20 0.54
DRD1 P21728 1/20 0.54
TBXA2R P21731 1/20 0.54
ACHE P22303 1/20 0.54
SLC6A2 P23975 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10988860 0.89 CYP3A4 (0.69) CYP3A4LMNAFYNCYP51A1NR1I2
SCHEMBL10988862 0.89 CYP3A4 (0.69) CYP3A4LMNAFYNCYP51A1NR1I2
SCHEMBL1152900 0.83 CYP3A4 (0.68) CYP3A4LMNAFYNCYP51A1NR1I2
SCHEMBL10987052 0.81 CYP3A4 (0.74) CYP3A4LMNAFYNCYP51A1NR1I2
SCHEMBL10987059 0.81 CYP3A4 (0.74) CYP3A4LMNAFYNCYP51A1NR1I2
SCHEMBL11401553 0.79 CYP3A4 (0.65) CYP3A4LMNAFYNCYP51A1NR1I2
SCHEMBL11380482 0.79 CYP3A4 (0.65) CYP3A4LMNAFYNCYP51A1NR1I2
Hydrochloric Acid SCHEMBL10986880 0.79 CYP3A4 (0.72) CYP3A4LMNAFYNCYP51A1NR1I2
Hydrochloric Acid SCHEMBL10986883 0.79 CYP3A4 (0.72) CYP3A4LMNAFYNCYP51A1NR1I2
SCHEMBL10980518 0.78 CYP3A4 (0.78) CYP3A4LMNACYP51A1NR1I2HSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0006722-B1 DERIVATIVES OF (4-(PIPERAZIN-1-YL-PHENYLOXYMETHYL)-1.3-DIOXOLAN-2-YLMETHYL)-1H-IMIDAZOLES AND -1H-1.2.4-TRIAZOLES, THEIR PREPARATION AND USE AS FUNGICIDES AND BACTERICIDES JANSSEN PHARMACEUTICA N.V. (BE) 1984-09-05 EP disclosed