Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 4/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2257980 | 0.80 | TDP1 (0.64) | TDP1L3MBTL1ALDH1A1TSHRMAPT | |
| SCHEMBL3824611 | 0.80 | TDP1 (0.64) | TDP1L3MBTL1ALDH1A1TSHRMAPT | |
| SCHEMBL29197128 | 0.78 | TDP1 (0.57) | TDP1L3MBTL1ALDH1A1TSHRMAPK1 | |
| SCHEMBL27448270 | 0.78 | TSHR (0.62) | TDP1L3MBTL1KDM4EGLAALDH1A1 | |
| SCHEMBL10654458 | 0.77 | TDP1 (0.56) | HCAR3TDP1L3MBTL1ALDH1A1TSHR | |
| SCHEMBL1448267 | 0.77 | TDP1 (0.56) | TDP1L3MBTL1KDM4EALDH1A1TSHR | |
| SCHEMBL31146201 | 0.77 | TDP1 (0.56) | TDP1L3MBTL1KDM4EALDH1A1TSHR | |
| SCHEMBL11091159 | 0.77 | TDP1 (0.56) | TDP1L3MBTL1KDM4EALDH1A1TSHR | |
| SCHEMBL3826317 | 0.76 | TDP1 (0.62) | HCAR3TDP1L3MBTL1TSHRLMNA | |
| SCHEMBL9847247 | 0.75 | MAPT (0.46) | HCAR3TDP1KDM4EGLAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4455311-A | Imidazoquinazoline derivatives which inhibit the aggregation of blood platelets, inhibit gastric secretion or have activity on the circulatory system | HOFFMANN-LA ROCHE INC. (US) | 1984-06-19 | — | — | US | disclosed |
| EP-0073060-A1 | Imidazoquinazoline derivatives, their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1983-03-02 | — | — | EP | disclosed |