Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.54 |
| ▸ | DHODH | Q02127 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3435546 | 0.87 | MAPT (0.47) | MAPTMAPK1KMT2AADORA3MEN1 | |
| SCHEMBL2730507 | 0.83 | PHGDH (0.58) | MAPTKMT2AMEN1CA1CA2 | |
| SCHEMBL10957361 | 0.80 | CA12 (0.47) | MAPTKMT2AMEN1GAACA1 | |
| SCHEMBL30722849 | 0.80 | HDAC3 (0.56) | MAPTGAACA1CA2CA12 | |
| SCHEMBL11073103 | 0.80 | CYP1A2 (0.53) | MAPTMAPK1KMT2AMEN1CA1 | |
| SCHEMBL4298598 | 0.80 | PHGDH (0.59) | GAACA1CA2CA12CA9 | |
| SCHEMBL30722873 | 0.78 | CA12 (0.48) | MAPK1CA1CA2CA12CA9 | |
| SCHEMBL10960030 | 0.78 | CA12 (0.48) | MAPTKMT2ACA1CA2CA12 | |
| SCHEMBL2362545 | 0.77 | CA12 (0.47) | MAPTADORA3CA1CA2CA12 | |
| SCHEMBL2203018 | 0.77 | CA12 (0.47) | MAPTKMT2AMEN1GAACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0112623-A2 | 3-Aryl-5-pyrazole-carboxylic-acid derivatives, their preparation and pharmaceutical compositions | ELI LILLY AND COMPANY (US) | 1984-07-04 | — | — | EP | disclosed |