Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 0.55 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11079915 | 0.85 | SLC6A4 (0.46) | SLC6A4MAOASLC6A2SLC6A3NOS3 | |
| SCHEMBL20032404 | 0.79 | SLC6A4 (0.63) | SLC6A4MAOASLC6A2SLC6A3 | |
| SCHEMBL3405625 | 0.78 | TAAR1 (0.57) | SLC6A4MAOASLC6A2SLC6A3NOS3 | |
| SCHEMBL11076527 | 0.78 | SLC6A4 (0.48) | SLC6A4MAOA | |
| SCHEMBL11082949 | 0.74 | SLC6A4 (0.47) | SLC6A4MAOASLC6A2SLC6A3NOS3 | |
| SCHEMBL3667006 | 0.73 | CYP1A2 (0.42) | — | |
| SCHEMBL11079937 | 0.73 | IDO1 (0.46) | NOS3NOS1 | |
| SCHEMBL11080931 | 0.72 | SLC6A4 (0.46) | SLC6A4MAOASLC6A2SLC6A3 | |
| SCHEMBL12214194 | 0.72 | SLC6A4 (0.54) | SLC6A4MAOASLC6A2SLC6A3NOS3 | |
| SCHEMBL7330731 | 0.71 | SLC6A4 (0.59) | SLC6A4MAOASLC6A2SLC6A3NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0024776-B1 | 4-PHENYL AND 5-PHENYL-1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAID DERIVATIVES, AND PROCESS FOR PREPARING SAID DERIVATIVES | SYNTEX (U.S.A.) INC. (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| US-4261995-A | DISORDERS OF CENTRAL NERVOUS SYSTEM AND CARDIOVASCULAR SYSTEM; HYPOTENSIVE | SYNTEX (U.S.A.) INC. (US) | 1981-04-14 | — | — | US | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |