Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 6/20 | 0.51 |
| ▸ | PGR | P06401 | 3/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.44 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.44 |
| ▸ | ALB | P02768 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL11080263 | 1.00 | NR1I2 (0.51) | NR1I2PGRPPARGESR1TDP1 | |
| Iodide SCHEMBL11080262 | 1.00 | NR1I2 (0.51) | NR1I2PGRPPARGESR1TDP1 | |
| SCHEMBL11041666 | 0.99 | NR1I2 (0.52) | NR1I2PGRPPARGESR1TDP1 | |
| Hydrochloric Acid SCHEMBL11089996 | 0.99 | NR1I2 (0.51) | NR1I2PGRPPARGESR1TDP1 | |
| Hydrochloric Acid SCHEMBL11090004 | 0.99 | NR1I2 (0.51) | NR1I2PGRPPARGESR1TDP1 | |
| Hydrochloric Acid SCHEMBL11090002 | 0.99 | NR1I2 (0.51) | NR1I2PGRPPARGESR1TDP1 | |
| Thiocyanic Acid SCHEMBL11080935 | 0.95 | TDP1 (0.49) | NR1I2PGRPPARGESR1TDP1 | |
| Thiocyanic Acid SCHEMBL11080940 | 0.95 | TDP1 (0.49) | NR1I2PGRPPARGESR1TDP1 | |
| Thiocyanic Acid SCHEMBL11080944 | 0.95 | TDP1 (0.49) | NR1I2PGRPPARGESR1TDP1 | |
| SCHEMBL11042443 | 0.94 | NR1I2 (0.58) | NR1I2PGRPPARGESR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4425340-A | ANTIBIOTICS, BACTERICIDES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1984-01-10 | — | — | US | disclosed |
| US-4390534-A | ANTIBIOTICS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-06-28 | — | — | US | disclosed |
| EP-0027599-A2 | Cephem compounds, processes for their preparation and pharmaceutical compositions containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-04-29 | — | — | EP | disclosed |