Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | NME2 | P22392 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11081819 | 1.00 | POLB (0.57) | POLBMEN1KMT2AHPGDNPSR1 | |
| SCHEMBL10857507 | 0.93 | MEN1 (0.60) | MEN1KMT2ANPC1RAB9AALOX5 | |
| SCHEMBL10857514 | 0.93 | MEN1 (0.60) | MEN1KMT2ANPC1RAB9AALOX5 | |
| SCHEMBL11088835 | 0.92 | HPGD (0.59) | POLBMEN1KMT2AHPGDNPSR1 | |
| SCHEMBL11088838 | 0.92 | HPGD (0.59) | POLBMEN1KMT2AHPGDNPSR1 | |
| SCHEMBL11081932 | 0.90 | POLB (0.56) | POLBMEN1KMT2AHPGDNME2 | |
| SCHEMBL11081930 | 0.90 | POLB (0.56) | POLBMEN1KMT2AHPGDNME2 | |
| SCHEMBL11085732 | 0.89 | MEN1 (0.64) | POLBMEN1KMT2AHPGDNPSR1 | |
| SCHEMBL11085731 | 0.89 | MEN1 (0.64) | POLBMEN1KMT2AHPGDNPSR1 | |
| SCHEMBL11086231 | 0.89 | MEN1 (0.54) | POLBMEN1KMT2AHPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4428952-A | Substituted pyrrolo[2,1-b]quinazolines and pyrido[2,1-b]quinazolines useful for the treatment of or the prevention of gastrointestinal ulcers | FARMITALIA CARLO ERBA S.P.A. (IT) | 1984-01-31 | — | — | US | disclosed |