SCHEMBL11084454

SCHEMBL11084454

CCN1CC2CC2(c2ccc(N)cc2)C1

nearest known ligand 0.63

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 4/20 0.54
DRD2 P14416 2/20 0.54
DRD3 P35462 2/20 0.54
CYP2D6 P10635 2/20 0.44
SLC6A2 P23975 2/20 0.44
SLC6A4 P31645 2/20 0.44
SLC6A3 Q01959 2/20 0.44
CYP1A1 P04798 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2C19 P33261 1/20 0.44
CYP19A1 P11511 2/20 0.43
KDM4E B2RXH2 1/20 0.39
GAA P10253 1/20 0.39
MAPT P10636 1/20 0.39
RAD52 P43351 1/20 0.39
GFER P55789 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4075128 0.86 KCNH2 (0.52) KCNH2DRD2DRD3CYP2D6SLC6A2
SCHEMBL14615319 0.86 KCNH2 (0.52) KCNH2DRD2DRD3CYP2D6SLC6A2
SCHEMBL6002385 0.86 KCNH2 (0.52) KCNH2DRD2DRD3CYP2D6SLC6A2
SCHEMBL6003339 0.86 KCNH2 (0.52) KCNH2DRD2DRD3CYP2D6SLC6A2
SCHEMBL4073749 0.84 KCNH2 (0.51) KCNH2DRD2DRD3CYP2D6SLC6A2
Hydrochloric Acid SCHEMBL5437235 0.84 KCNH2 (0.51) KCNH2DRD2DRD3CYP2D6SLC6A2
SCHEMBL11077313 0.84 KCNH2 (0.54) KCNH2DRD2DRD3CYP2D6SLC6A2
SCHEMBL7031873 0.84 KCNH2 (0.50) KCNH2DRD2DRD3CYP2D6SLC6A2
SCHEMBL13312896 0.84 KCNH2 (0.50) KCNH2DRD2DRD3CYP2D6SLC6A2
SCHEMBL13312895 0.84 KCNH2 (0.50) KCNH2DRD2DRD3CYP2D6SLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4435419-A Method of treating depression using azabicyclohexanes AMERICAN CYANAMID COMPANY (US) 1984-03-06 US disclosed
US-4231935-A ANXIOLYTICS AND ANALGESICS AMERICAN CYANAMID COMPANY (US) 1980-11-04 US disclosed
US-4196120-A 1,2-BIS(HYDROCARBYLSULFONYLOXY OR HALO METHYL)CYCLOPROPYLBENZENE, OPTICAL ACITIVITY ANALGESICS AMERICAN CYANAMID COMPANY (US) 1980-04-01 US disclosed
US-4131611-A ANXIOLYTIC, ANALGESIC AMERICAN CYANAMID COMPANY (US) 1978-12-26 US disclosed