Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 4/20 | 0.59 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.59 |
| ▸ | FER | P16591 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 1/20 | 0.59 |
| ▸ | MARK3 | P27448 | 1/20 | 0.59 |
| ▸ | FLT4 | P35916 | 1/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.59 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.59 |
| ▸ | CLK2 | P49760 | 1/20 | 0.59 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.59 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.59 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.59 |
| ▸ | STK3 | Q13188 | 1/20 | 0.59 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.59 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4443346 | 0.87 | MKNK1 (0.56) | TTKDCLK1PRKD3MAP4K4CHEK2 | |
| SCHEMBL1903657 | 0.85 | TTK (0.82) | TTKCLK2DYRK1AIDO1PIM1 | |
| SCHEMBL8446250 | 0.81 | AURKA (0.69) | TTKCHEK2AURKBMAPK1 | |
| SCHEMBL13207885 | 0.81 | PIM1 (0.51) | TTKDCLK1PRKD3MAP4K4CHEK2 | |
| SCHEMBL28643797 | 0.80 | IDO1 (0.65) | TTKMKNK1HPGDKDM4EALDH1A1 | |
| SCHEMBL2564024 | 0.80 | TTK (0.70) | TTKMAP2K4 | |
| SCHEMBL16025573 | 0.79 | TTK (0.48) | TTKDYRK1AMKNK1MAPTIDO1 | |
| SCHEMBL12074459 | 0.78 | MAPK1 (0.53) | TTKMAPK1 | |
| SCHEMBL13207082 | 0.78 | LRRK2 (0.46) | TTKHPGDMAPTALDH1A1KIF11 | |
| SCHEMBL4432759 | 0.78 | PDPK1 (0.67) | MAP4K4CHEK2CSF1RFERCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055450-B1 | PYRAZOLOINDAZOLE DERIVATIVES, PROCESS FOR PREPARING THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Chugai Seiyaku Kabushiki Kaisha (JP) | 1984-12-05 | — | — | EP | disclosed |
| US-4415569-A | BRONCHODILATORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 1983-11-15 | — | — | US | disclosed |
| EP-0055450-A1 | Pyrazoloindazole derivatives, process for preparing the same, and pharmaceutical composition containing the same | Chugai Seiyaku Kabushiki Kaisha (JP) | 1982-07-07 | — | — | EP | disclosed |