Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.58 |
| ▸ | ABL1 | P00519 | 4/20 | 0.58 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.58 |
| ▸ | PIM1 | P11309 | 3/20 | 0.58 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.58 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.58 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.58 |
| ▸ | PRKACA | P17612 | 2/20 | 0.58 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.58 |
| ▸ | LTK | P29376 | 1/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.58 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.58 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.58 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.58 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.58 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11079649 | 0.98 | EGFR (0.57) | EGFRABL1MAP4K4PIM1MAP4K2 | |
| Hydrochloric Acid SCHEMBL8808309 | 0.86 | KDR (0.64) | EGFRABL1MAP4K4PIM1MAP4K2 | |
| SCHEMBL31162309 | 0.86 | EGFR (0.68) | EGFRABL1ERBB2MAPK14FADS1 | |
| SCHEMBL11088154 | 0.86 | EGFR (0.68) | EGFRABL1ERBB2MAPK14FADS1 | |
| Hydrochloric Acid SCHEMBL11091518 | 0.85 | EGFR (0.68) | EGFRABL1ERBB2MAPK14FADS1 | |
| Hydrochloric Acid SCHEMBL8807754 | 0.82 | EGFR (0.67) | EGFRAURKBCLK4ERBB2MKNK2 | |
| SCHEMBL13042322 | 0.77 | EGFR (0.74) | EGFRABL1MAP4K4PIM1MAP4K2 | |
| SCHEMBL11092859 | 0.74 | EGFR (0.58) | EGFRABL1MAP4K4PIM1MAP4K2 | |
| SCHEMBL8920 | 0.74 | EGFR (1.00) | EGFRABL1MAP4K4PIM1MAP4K2 | |
| SCHEMBL29941271 | 0.74 | EGFR (1.00) | EGFRABL1MAP4K4PIM1MAP4K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-55038325-A | — | — | None | — | — | JP | disclosed |
| US-4464375-A | ANALGESIC, ANTIINFLAMMATORY | SANKYO CO., LTD. (JP) | 1984-08-07 | — | — | US | disclosed |
| US-4322420-A | Method of using 4-anilinoquinazoline derivatives as analgesic and anti-inflammatory agents | SANKYO COMPANY LIMITED (JP) | 1982-03-30 | — | — | US | disclosed |
| JP-S5538325-A | 4-ANILINOQUINAZOLINE DERIVATIVE AND ITS PREPARATION | SANKYO CO LTD | 1980-03-17 | — | — | JP | disclosed |