Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 17/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11086556 | 0.86 | AR (0.78) | ARMEN1LMNATP53CYP1A2 | |
| SCHEMBL11079218 | 0.86 | AR (1.00) | ARMEN1LMNATP53CYP1A2 | |
| SCHEMBL8004308 | 0.86 | AR (0.60) | ARMEN1LMNATP53CYP1A2 | |
| SCHEMBL11481148 | 0.83 | AR (0.51) | ARMEN1LMNAALOX12KMT2A | |
| SCHEMBL2221478 | 0.81 | AR (0.78) | ARPGR | |
| SCHEMBL11482187 | 0.81 | KMT2A (0.52) | ARMEN1LMNACYP1A2CYP2C9 | |
| SCHEMBL8407306 | 0.80 | AR (0.78) | ARMEN1LMNATP53CYP1A2 | |
| SCHEMBL4031754 | 0.78 | AR (0.79) | ARMEN1LMNATP53CYP1A2 | |
| SCHEMBL11568388 | 0.77 | AR (0.62) | ARMEN1LMNATP53CYP1A2 | |
| SCHEMBL332642 | 0.76 | AR (0.76) | ARMEN1LMNATP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4482739-A | INTERMEDIATES FOR ANTIANDROGENS AND PARASITICIDES | HOFFMANN-LA ROCHE INC. (US) | 1984-11-13 | — | — | US | disclosed |
| US-4407814-A | ANTIANDROGENS, 3-(HALO- AND/OR TRIFULOROMETHYL-PHENYL)-4,4-DIMETHYL-HYDANTOINS AND IMINO DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 1983-10-04 | — | — | US | disclosed |
| EP-0001813-B1 | IMIDAZOLIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION, INTERMEDIATES FOR USE IN THIS PROCESS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE USE OF THE ACTIVE COMPOUNDS | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-11-04 | — | — | EP | disclosed |
| EP-0001813-A1 | Imidazolidine derivatives, process for their preparation, intermediates for use in this process, pharmaceutical compositions containing them and the use of the active compounds | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1979-05-16 | — | — | EP | disclosed |