Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.79 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.79 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.79 |
| ▸ | PLG | P00747 | 1/20 | 0.66 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.61 |
| ▸ | TUBB | P07437 | 2/20 | 0.61 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.61 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.61 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.61 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.61 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.61 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10534553 | 0.89 | ABCG2 (0.84) | ABCG2ABCB1ABCC1PLGNOX4 | |
| Retusin SCHEMBL1421755 | 0.89 | ABCG2 (1.00) | ABCG2ABCB1ABCC1PLGNOX4 | |
| Retusin SCHEMBL29496204 | 0.89 | ABCG2 (1.00) | ABCG2ABCB1ABCC1PLGNOX4 | |
| Retusin SCHEMBL4279671 | 0.88 | ABCG2 (0.98) | ABCG2ABCB1ABCC1PLGNOX4 | |
| SCHEMBL11098578 | 0.86 | ABCG2 (0.64) | ABCG2ABCB1ABCC1PLGNOX4 | |
| SCHEMBL11100636 | 0.85 | ABCG2 (0.76) | ABCG2ABCB1ABCC1PLGNOX4 | |
| Pachypodol SCHEMBL29929114 | 0.84 | ABCG2 (1.00) | ABCG2ABCB1ABCC1PLGNOX4 | |
| Pachypodol SCHEMBL39280 | 0.84 | ABCG2 (1.00) | ABCG2ABCB1ABCC1PLGNOX4 | |
| Ayanin SCHEMBL1252843 | 0.84 | ABCG2 (1.00) | ABCG2ABCB1ABCC1PLGNOX4 | |
| Bromide SCHEMBL11282619 | 0.84 | ABCG2 (0.74) | ABCG2ABCB1ABCC1PLGNOX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0019081-B1 | FLAVONE DERIVATIVES, THEIR PREPARATION, THESE NOVEL AND KNOWN FLAVONES AS ANTIVIRAL AGENTS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-10-24 | — | — | EP | claimed |
| US-4352792-A | 3-Alkoxyflavone antiviral agents | HOFFMANN-LA ROCHE INC. (US) | 1982-10-05 | — | — | US | claimed |
| EP-0019081-A1 | Flavone derivatives, their preparation, these novel and known flavones as antiviral agents, and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-11-26 | — | — | EP | claimed |
| EP-0019081-B1 | FLAVONE DERIVATIVES, THEIR PREPARATION, THESE NOVEL AND KNOWN FLAVONES AS ANTIVIRAL AGENTS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-10-24 | — | — | EP | disclosed |
| US-4352792-A | 3-Alkoxyflavone antiviral agents | HOFFMANN-LA ROCHE INC. (US) | 1982-10-05 | — | — | US | disclosed |
| EP-0019081-A1 | Flavone derivatives, their preparation, these novel and known flavones as antiviral agents, and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-11-26 | — | — | EP | disclosed |