Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 11/20 | 0.49 |
| ▸ | PREP | P48147 | 4/20 | 0.47 |
| ▸ | FAP | Q12884 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11106704 | 0.93 | ACE (0.48) | ACEPREPFAPLMNAACE2 | |
| SCHEMBL11109719 | 0.93 | ACE (0.48) | ACEPREPFAPLMNAACE2 | |
| SCHEMBL22209483 | 0.86 | PREP (0.52) | ACEPREPFAPLMNAACE2 | |
| SCHEMBL11104635 | 0.84 | ACE (0.55) | ACEPREPFAPLMNAACE2 | |
| SCHEMBL29749309 | 0.80 | ACE (0.71) | ACEPREPFAPACE2 | |
| SCHEMBL11435575 | 0.80 | ACE (0.71) | ACEPREPFAPACE2 | |
| SCHEMBL3472327 | 0.80 | ACE (0.71) | ACEPREPFAPACE2 | |
| SCHEMBL22811264 | 0.80 | ACE (0.57) | ACEPREPFAPLMNAACE2 | |
| SCHEMBL11103510 | 0.79 | ACE (0.46) | ACEPREPFAPLMNAACE2 | |
| SCHEMBL22811043 | 0.78 | ACE (0.50) | ACEPREPFAPLMNAACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4456595-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1984-06-26 | — | — | US | disclosed |