Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 4/20 | 0.36 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.36 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11099927 | 1.00 | CYP1A2 (0.46) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 | |
| SCHEMBL8442549 | 1.00 | CYP1A2 (0.46) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 | |
| Methane SCHEMBL11101214 | 0.99 | CYP1A2 (0.45) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 | |
| Methane SCHEMBL11101210 | 0.99 | CYP1A2 (0.45) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 | |
| SCHEMBL11174831 | 0.99 | CYP1A2 (0.47) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 | |
| SCHEMBL8443113 | 0.99 | CYP1A2 (0.47) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 | |
| SCHEMBL11174820 | 0.99 | CYP1A2 (0.47) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL11235152 | 0.98 | CYP1A2 (0.46) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL11192220 | 0.98 | CYP1A2 (0.46) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL11235157 | 0.98 | CYP1A2 (0.46) | CYP1A2CYP2C9CYP2C19MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028064-B1 | CHROMANOL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION COMPRISING THEM | BEECHAM GROUP PLC (GB) | 1983-07-20 | — | — | EP | claimed |
| EP-0033612-B1 | PYRANO DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND ANTIHYPERTENSIVE COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1984-04-11 | — | — | EP | disclosed |
| EP-0028064-B1 | CHROMANOL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION COMPRISING THEM | BEECHAM GROUP PLC (GB) | 1983-07-20 | — | — | EP | disclosed |
| US-4363811-A | Anti-hypertensive chromanol derivatives | BEECHAM GROUP LIMITED (GB) | 1982-12-14 | — | — | US | disclosed |
| US-4327099-A | HYPOTENSIVE AGENTS, PYRANO(2,3-F)BENZIMIDAZOLE | BEECHAM GROUP LIMITED (GB) | 1982-04-27 | — | — | US | disclosed |
| EP-0033612-A1 | Pyrano derivatives, a process for their preparation and antihypertensive compositions containing them | BEECHAM GROUP PLC (GB) | 1981-08-12 | — | — | EP | disclosed |
| EP-0028064-A1 | Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them | BEECHAM GROUP PLC (GB) | 1981-05-06 | — | — | EP | disclosed |