Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL307912 | 0.89 | CA12 (0.56) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL11437720 | 0.88 | SMN1; SMN2 (0.70) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL11258821 | 0.86 | SMN1; SMN2 (0.57) | ALDH1A1LMNASMN1; SMN2NPC1MAPT | |
| SCHEMBL27891607 | 0.85 | HDAC1 (0.55) | NR1H4HDAC1HDAC8HDAC6SMPD1 | |
| SCHEMBL6718805 | 0.81 | NPC1 (0.63) | ALDH1A1NPC1RAB9AMAPTMEN1 | |
| SCHEMBL1515747 | 0.81 | NPC1 (0.63) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL28859140 | 0.80 | NR1H4 (0.82) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL29668496 | 0.79 | MEN1 (0.71) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL28881824 | 0.79 | MEN1 (0.71) | ALDH1A1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL22551314 | 0.79 | PTPN7 (0.46) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0040956-B1 | 8-SUBSTITUTED 4-(3,4-DIHYDROXYPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINES | SMITHKLINE BECKMAN CORPORATION (US) | 1984-10-31 | — | — | EP | disclosed |
| US-4340600-A | Renal dilating methods and compositions using 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines | SMITHKLINE CORPORATION (US) | 1982-07-20 | — | — | US | disclosed |
| EP-0040956-A1 | 8-Substituted 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines | SMITHKLINE BECKMAN CORPORATION (US) | 1981-12-02 | — | — | EP | disclosed |