Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10602986 | 0.88 | TSHR (0.49) | TSHRTDP1AKR1B1 | |
| SCHEMBL17606122 | 0.84 | TSHR (1.00) | TSHRTDP1AKR1B1 | |
| SCHEMBL17605022 | 0.84 | TSHR (1.00) | TSHRTDP1AKR1B1 | |
| SCHEMBL30236599 | 0.84 | TSHR (1.00) | TSHRTDP1AKR1B1 | |
| SCHEMBL10599632 | 0.84 | TSHR (1.00) | TSHRTDP1AKR1B1 | |
| SCHEMBL10604226 | 0.82 | TSHR (0.55) | TSHRTDP1AKR1B1 | |
| SCHEMBL1395366 | 0.76 | AKR1B1 (1.00) | TSHRTDP1AKR1B1 | |
| SCHEMBL17604915 | 0.73 | AKR1B1 (0.52) | TSHRTDP1AKR1B1 | |
| SCHEMBL10601680 | 0.72 | TSHR (0.49) | TSHRTDP1AKR1B1 | |
| SCHEMBL7737577 | 0.71 | TSHR (0.46) | TSHRTDP1AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0115133-A1 | Spiro-3-hetero-azolones for treatment of diabetic complications | PFIZER INC. (US) | 1984-08-08 | — | — | EP | disclosed |