Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10660359 | 0.85 | TDP1 (0.57) | TDP1TSHRMAPTHPGDPOLB | |
| SCHEMBL11004754 | 0.81 | TDP1 (0.50) | TDP1TSHRMAPTHPGDPOLB | |
| SCHEMBL11004748 | 0.81 | TDP1 (0.50) | TDP1TSHRMAPTHPGDPOLB | |
| SCHEMBL9691470 | 0.81 | HPGD (0.57) | CD274MAPTHPGDALDH1A1KDM4E | |
| SCHEMBL9691464 | 0.81 | HPGD (0.57) | CD274MAPTHPGDALDH1A1KDM4E | |
| SCHEMBL33262 | 0.80 | TDP1 (0.61) | TDP1TSHRCD274MAPTPOLB | |
| SCHEMBL8145097 | 0.78 | TDP1 (0.59) | TDP1TSHRCD274MAPTPOLB | |
| SCHEMBL166433 | 0.78 | TDP1 (0.58) | TDP1TSHRCD274HPGDPOLB | |
| SCHEMBL9601923 | 0.77 | TSHR (0.56) | TDP1TSHRCD274MAPTHPGD | |
| SCHEMBL9601917 | 0.77 | TSHR (0.56) | TDP1TSHRCD274MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0109049-A2 | Process for preparation of substituted dihydropyridines and intermediates therefor | USV PHARMACEUTICAL CORPORATION (US) | 1984-05-23 | — | — | EP | disclosed |