Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HK1 | P19367 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GALK1 | P51570 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30059612 | 0.76 | MAPT (0.53) | MAPTGAAARBRD4CREBBP | |
| SCHEMBL1736809 | 0.73 | CREBBP (0.55) | MAPTGAAARBRD4CREBBP | |
| SCHEMBL29572486 | 0.73 | CREBBP (0.55) | MAPTGAAARBRD4CREBBP | |
| SCHEMBL27764354 | 0.73 | MAPT (0.50) | MAPTGAAARBRD4CREBBP | |
| SCHEMBL12837999 | 0.73 | CREBBP (0.55) | MAPTGAAARBRD4CREBBP | |
| SCHEMBL11207070 | 0.73 | MAPT (0.50) | MAPTGAAARBRD4CREBBP | |
| SCHEMBL31517110 | 0.73 | MAPT (0.55) | MAPTGAAARBRD4CREBBP | |
| SCHEMBL6954505 | 0.73 | MAPT (0.50) | MAPTGAAARBRD4CREBBP | |
| SCHEMBL2781001 | 0.73 | MAPT (0.55) | MAPTGAAARBRD4CREBBP | |
| SCHEMBL26425605 | 0.73 | GAA (0.50) | MAPTGAAARBRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4460594-A | CENTRAL NERVOUS SYSTEM DISORDERS | BEECHAM GROUP P.L.C. (GB) | 1984-07-17 | — | — | US | disclosed |
| EP-0077607-A1 | N-substituted 3-aryl piperidines and derivatives thereof | BEECHAM GROUP PLC (GB) | 1983-04-27 | — | — | EP | disclosed |