Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.55 |
| ▸ | CDK8 | P49336 | 3/20 | 0.55 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.55 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.55 |
| ▸ | MET | P08581 | 1/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.50 |
| ▸ | RET | P07949 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.50 |
| ▸ | LTK | P29376 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.45 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11117278 | 0.91 | ROCK1 (0.60) | ROCK1PDGFRBCDK8NTRK3NTRK2 | |
| SCHEMBL11117404 | 0.90 | ROCK1 (0.57) | ROCK1PDGFRBCDK8NTRK3NTRK2 | |
| SCHEMBL11115564 | 0.85 | ROCK1 (0.62) | ROCK1PDGFRBCDK8NTRK3NTRK2 | |
| SCHEMBL11133483 | 0.84 | ROCK1 (0.53) | ROCK1PDGFRBCDK8NTRK3NTRK2 | |
| SCHEMBL11121579 | 0.84 | ROCK1 (0.53) | ROCK1PDGFRBCDK8NTRK3NTRK2 | |
| SCHEMBL11113634 | 0.83 | ROCK1 (0.55) | ROCK1PDGFRBCDK8NTRK3NTRK2 | |
| SCHEMBL11119511 | 0.82 | PDGFRB (0.58) | ROCK1PDGFRBCDK8NTRK3NTRK2 | |
| SCHEMBL11117812 | 0.82 | PDGFRB (0.61) | ROCK1PDGFRBCDK8NTRK3NTRK2 | |
| SCHEMBL11113507 | 0.81 | ROCK1 (0.57) | ROCK1PDGFRBCDK8NTRK3NTRK2 | |
| SCHEMBL11121345 | 0.80 | PDGFRB (0.62) | ROCK1PDGFRBCDK8NTRK3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116853-A1 | Pyridazinones, processes for preparing them, therapeutical compositions containing these compounds and their use | BASF Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |