Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.31 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11120393 | 0.86 | MEN1 (0.40) | MEN1KMT2ATDP1PKMRAB9A | |
| SCHEMBL11120296 | 0.86 | TSHR (0.36) | MEN1KMT2ARAB9ATSHRALDH1A1 | |
| SCHEMBL11122089 | 0.84 | MEN1 (0.38) | MEN1KMT2ATDP1PKMRAB9A | |
| SCHEMBL11120094 | 0.83 | TSHR (0.35) | MEN1KMT2ARAB9ATSHRNPY5R | |
| Water SCHEMBL11122287 | 0.82 | TSHR (0.34) | MEN1KMT2ARAB9ATSHRNPY5R | |
| SCHEMBL11119079 | 0.82 | MEN1 (0.37) | MEN1KMT2ATDP1PKMRAB9A | |
| SCHEMBL11116736 | 0.81 | MEN1 (0.40) | FAAHMEN1KMT2ATDP1PKM | |
| SCHEMBL11120103 | 0.80 | NPY5R (0.45) | TSHRNPY5R | |
| SCHEMBL11123858 | 0.80 | HDAC3 (0.37) | TSHRMAPTGAA | |
| SCHEMBL11118646 | 0.79 | MEN1 (0.37) | FAAHMEN1KMT2ATDP1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129408-A2 | (3-alkyl-5-isothiazolyl)ureas | ELI LILLY AND COMPANY (US) | 1984-12-27 | — | — | EP | claimed |
| EP-0129408-A2 | (3-alkyl-5-isothiazolyl)ureas | ELI LILLY AND COMPANY (US) | 1984-12-27 | — | — | EP | disclosed |