Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.39 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11116736 | 0.85 | MEN1 (0.40) | SMARCA2SMARCA4MEN1APAF1TDP2 | |
| SCHEMBL11118756 | 0.85 | SMARCA2 (0.33) | SMARCA2SMARCA4MEN1APAF1TDP2 | |
| SCHEMBL11133024 | 0.83 | ABCC1 (0.41) | SMARCA2SMARCA4HTTTSHRKDM4E | |
| SCHEMBL11122319 | 0.83 | HDAC3 (0.40) | SMARCA2SMARCA4HDAC3HDAC1HDAC2 | |
| SCHEMBL14445029 | 0.81 | GAA (0.42) | SMARCA2SMARCA4TSHRKDM4EAURKA | |
| SCHEMBL11120296 | 0.78 | TSHR (0.36) | SMARCA2SMARCA4HTTAPEX1TSHR | |
| SCHEMBL11402099 | 0.78 | SMARCA2 (0.50) | SMARCA2SMARCA4HTTAPEX1TSHR | |
| SCHEMBL11119842 | 0.74 | SMARCA2 (0.39) | SMARCA2SMARCA4HTTAPEX1TSHR | |
| SCHEMBL11121478 | 0.74 | SMARCA2 (0.34) | SMARCA2SMARCA4 | |
| SCHEMBL11115792 | 0.74 | SMARCA2 (0.34) | SMARCA2SMARCA4HTTMEN1APAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0129408-A2 | (3-alkyl-5-isothiazolyl)ureas | ELI LILLY AND COMPANY (US) | 1984-12-27 | — | — | EP | claimed |
| EP-0129408-A2 | (3-alkyl-5-isothiazolyl)ureas | ELI LILLY AND COMPANY (US) | 1984-12-27 | — | — | EP | disclosed |