Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 7/20 | 0.42 |
| ▸ | ESR1 | P03372 | 5/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 4/20 | 0.31 |
| ▸ | CA2 | P00918 | 4/20 | 0.31 |
| ▸ | ACHE | P22303 | 4/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11119283 | 0.88 | ESR2 (0.44) | ESR2ESR1 | |
| SCHEMBL11112663 | 0.85 | ESR2 (0.42) | ESR2ESR1GRM2 | |
| SCHEMBL11216695 | 0.79 | ESR2 (0.45) | ESR2ESR1 | |
| SCHEMBL11118556 | 0.77 | ESR2 (0.46) | ESR2ESR1 | |
| SCHEMBL11117814 | 0.76 | ESR2 (0.42) | ESR2ESR1GRM2 | |
| SCHEMBL11111847 | 0.76 | ESR2 (0.44) | ESR2ESR1 | |
| SCHEMBL11117661 | 0.76 | ESR2 (0.42) | ESR2ESR1 | |
| SCHEMBL11111816 | 0.75 | ESR2 (0.52) | ESR2ESR1GRM2 | |
| SCHEMBL11116722 | 0.73 | ESR2 (0.47) | ESR2ESR1GRM2 | |
| SCHEMBL11114978 | 0.72 | ESR2 (0.47) | ESR2ESR1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0027948-B1 | TETRAHYDRO-FLUORENE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | MERCK & CO. INC. (US) | 1984-03-21 | — | — | EP | disclosed |