Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 7/20 | 0.44 |
| ▸ | ESR1 | P03372 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11114410 | 0.94 | ESR2 (0.44) | ESR2ESR1HSD17B10MEN1KMT2A | |
| SCHEMBL11115088 | 0.93 | ESR2 (0.46) | ESR2ESR1HSD17B10MEN1KMT2A | |
| SCHEMBL11113198 | 0.92 | ESR2 (0.46) | ESR2ESR1HSD17B10MEN1KMT2A | |
| SCHEMBL11117661 | 0.92 | ESR2 (0.42) | ESR2ESR1HSD17B10MEN1KMT2A | |
| SCHEMBL11116505 | 0.91 | ESR2 (0.48) | ESR2ESR1HSD17B10MEN1KMT2A | |
| SCHEMBL11118556 | 0.90 | ESR2 (0.46) | ESR2ESR1HSD17B10MEN1KMT2A | |
| SCHEMBL11113220 | 0.89 | ESR2 (0.44) | ESR2ESR1HSD17B10MEN1KMT2A | |
| SCHEMBL11117231 | 0.89 | ESR2 (0.45) | ESR2ESR1HSD17B10MEN1KMT2A | |
| SCHEMBL11113070 | 0.88 | ESR2 (0.43) | ESR2ESR1HSD17B10MEN1KMT2A | |
| SCHEMBL11117258 | 0.88 | ESR2 (0.45) | ESR2ESR1HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0027948-B1 | TETRAHYDRO-FLUORENE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | MERCK & CO. INC. (US) | 1984-03-21 | — | — | EP | disclosed |