Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.65 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.62 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.62 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.62 |
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11290195 | 1.00 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DPRSS1 | |
| SCHEMBL11117845 | 1.00 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DPRSS1 | |
| SCHEMBL4823570 | 0.83 | PDE4A (0.90) | PDE4APDE4BPDE4CPDE4DPRSS1 | |
| SCHEMBL11079989 | 0.83 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPRSS1 | |
| SCHEMBL11079987 | 0.83 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPRSS1 | |
| SCHEMBL11343765 | 0.82 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPRSS1 | |
| SCHEMBL11120721 | 0.82 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPRSS1 | |
| SCHEMBL11120724 | 0.82 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPRSS1 | |
| SCHEMBL1162795 | 0.81 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPRSS1 | |
| SCHEMBL1162793 | 0.81 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013144191-A1 | SUBSTITUTED 2-AMINO-3-CYANOPYRIDINES AS INHIBITORS OF SODIUM-CALCIUM EXCHANGE AND USE THEREOF FOR CARDIOVASCULAR DISEASES | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2013-10-03 | — | — | WO | disclosed |
| EP-0129407-A2 | Improvements in and relating to (3-aryl-5-isothiazolyl)ureas | ELI LILLY AND COMPANY (US) | 1984-12-27 | — | — | EP | disclosed |
| US-4322421-A | 4-Phenyl-and 5-phenyl-1,4,5,6-tetrahydro-pyrimidine derivatives | SYNTEX (U.S.A.) INC. (US) | 1982-03-30 | — | — | US | disclosed |
| EP-0024776-A1 | 4-Phenyl and 5-phenyl-1,4,5,6-tetrahydropyrimidine derivatives, pharmaceutical compositions containing said derivatives, and process for preparing said derivatives | SYNTEX (U.S.A.) INC. (US) | 1981-03-11 | — | — | EP | disclosed |