Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | CDK8 | P49336 | 2/20 | 0.56 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.56 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.56 |
| ▸ | MET | P08581 | 1/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | RET | P07949 | 1/20 | 0.51 |
| ▸ | LTK | P29376 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11119511 | 0.93 | PDGFRB (0.58) | PDGFRBCDK8NTRK3NTRK2AURKB | |
| SCHEMBL11130962 | 0.89 | PDGFRB (0.60) | PDGFRBCDK8NTRK3NTRK2AURKB | |
| SCHEMBL11116211 | 0.88 | PDGFRB (0.58) | PDGFRBCDK8NTRK3NTRK2AURKB | |
| SCHEMBL11117812 | 0.88 | PDGFRB (0.61) | PDGFRBCDK8NTRK3NTRK2AURKB | |
| SCHEMBL11116417 | 0.87 | PDGFRB (0.57) | PDGFRBCDK8NTRK3NTRK2AURKB | |
| SCHEMBL10412999 | 0.87 | PDGFRB (0.60) | PDGFRBCDK8NTRK3NTRK2AURKB | |
| SCHEMBL11120457 | 0.85 | PDGFRB (0.53) | PDGFRBCDK8NTRK3NTRK2AURKB | |
| SCHEMBL11119155 | 0.85 | ROCK1 (0.61) | PDGFRBCDK8NTRK3NTRK2AURKB | |
| SCHEMBL11119270 | 0.85 | PDGFRB (0.55) | PDGFRBCDK8NTRK3NTRK2AURKB | |
| SCHEMBL11117204 | 0.84 | PDGFRB (0.63) | PDGFRBCDK8NTRK3NTRK2AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116853-A1 | Pyridazinones, processes for preparing them, therapeutical compositions containing these compounds and their use | BASF Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |