Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 20/20 | 0.62 |
| ▸ | RARB | P10826 | 18/20 | 0.62 |
| ▸ | RARA | P10276 | 17/20 | 0.62 |
| ▸ | RXRA | P19793 | 12/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.62 |
| ▸ | GMNN | O75496 | 1/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | THPO | P40225 | 1/20 | 0.62 |
| ▸ | MTOR | P42345 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11133312 | 1.00 | RARG (0.62) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL11122914 | 0.94 | RARG (0.65) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL7082929 | 0.94 | RARG (0.65) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL7085635 | 0.88 | RARG (0.78) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL7085637 | 0.88 | RARG (0.78) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL8522088 | 0.82 | RARG (0.61) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL8522090 | 0.82 | RARG (0.61) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL8950121 | 0.81 | RARG (0.60) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL8950115 | 0.81 | RARG (0.60) | RARGRARBRARARXRAKDM4E | |
| SCHEMBL11123385 | 0.81 | RARG (0.70) | RARGRARBRARARXRAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0058370-B1 | TETRAHYDRONAPHTHALENE AND INDAN COMPOUNDS, THEIR PRODUCTION AND PHARMACEUTICAL PREPARATIONS | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-12-12 | — | — | EP | disclosed |
| EP-0058370-A1 | Tetrahydronaphthalene and indan compounds, their production and pharmaceutical preparations | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-08-25 | — | — | EP | disclosed |