Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.65 |
| ▸ | MTOR | P42345 | 11/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.65 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.55 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.55 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | PRKDC | P78527 | 1/20 | 0.55 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1114143 | 0.89 | PIK3CA (0.59) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL1113809 | 0.86 | PIK3CA (0.78) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL1113838 | 0.86 | PIK3CA (0.65) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL1114198 | 0.85 | PIK3CA (0.63) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL4436001 | 0.84 | PIK3CA (0.64) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL1114252 | 0.83 | PIK3CA (0.55) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL1114193 | 0.83 | PIK3CA (0.68) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL3405383 | 0.83 | PIK3CA (0.55) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL1113472 | 0.82 | PIK3CA (0.67) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL17087314 | 0.82 | HDAC1 (0.82) | PIK3CAMTORPIK3CGPIK3CDHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279188-B1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2015-01-28 | — | — | EP | disclosed |
| CN-102105474-B | Purine PI3K inhibitor compounds and methods of use | GENENTECH INC | 2014-01-08 | — | — | CN | disclosed |
| US-8445487-B2 | Purine PI3K inhibitor compounds and methods of use | GENENTECH, INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-20120135988-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | CASTANEDO GEORGETTE (US) | 2012-05-31 | — | — | US | disclosed |
| US-8158624-B2 | Purine PI3K inhibitor compounds and methods of use | GENETECH, INC. (US) | 2012-04-17 | — | — | US | disclosed |
| CN-102105474-A | Purine PI3K inhibitor compounds and methods of use | GENENTECH INC | 2011-06-22 | — | — | CN | disclosed |
| EP-2279188-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-02-02 | — | — | EP | disclosed |
| US-20090318411-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. | 2009-12-24 | — | — | US | disclosed |
| WO-2009146406-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-12-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318411-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | PIK3CA, PIK3CD, PIK3CG | PIK3CA 1/4885MTOR 75/4885PIK3CG 3/4885 |
| US-20120135988-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | PIK3CA, PIK3CD, PIK3CG | PIK3CA 1/4885MTOR 75/4885PIK3CG 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.