Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.34 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20764905 | 0.83 | GAA (0.42) | DGAT2MAP3K5KDM4ETSHRALDH1A1 | |
| SCHEMBL29363550 | 0.83 | MAP3K5 (0.37) | DGAT2MAP3K5KDM4ETSHRALDH1A1 | |
| SCHEMBL29092783 | 0.83 | MAP3K5 (0.39) | DGAT2MAP3K5KDM4ETSHRALDH1A1 | |
| SCHEMBL29879089 | 0.83 | MAP3K5 (0.39) | DGAT2MAP3K5KDM4ETSHRALDH1A1 | |
| SCHEMBL1513052 | 0.83 | MAP3K5 (0.37) | DGAT2MAP3K5KDM4ETSHRALDH1A1 | |
| SCHEMBL24268660 | 0.83 | MAP3K5 (0.39) | DGAT2MAP3K5KDM4ETSHRALDH1A1 | |
| SCHEMBL19485522 | 0.83 | MAP3K5 (0.39) | DGAT2MAP3K5KDM4ETSHRALDH1A1 | |
| SCHEMBL14538892 | 0.83 | GAA (0.45) | DGAT2MAP3K5KDM4ETSHRALDH1A1 | |
| SCHEMBL21217456 | 0.82 | RET (0.37) | DGAT2KDM4EALDH1A1CYP4F2CYP4A11 | |
| SCHEMBL30592190 | 0.82 | MAP3K5 (0.39) | DGAT2MAP3K5KDM4ETSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279188-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009146406-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-12-03 | — | — | WO | disclosed |