Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7323638 | 0.91 | EPHX1 (0.46) | EPHX1CYP2D6MEN1ALDH1A1LMNA | |
| SCHEMBL8380130 | 0.80 | EPHX1 (0.34) | EPHX1SHBG | |
| SCHEMBL24438001 | 0.76 | EPHX1 (0.52) | EPHX1LMNATP53SIGMAR1 | |
| SCHEMBL1324615 | 0.76 | EPHX1 (0.41) | EPHX1CYP2D6MEN1ALDH1A1LMNA | |
| SCHEMBL3823377 | 0.74 | EPHX1 (0.44) | EPHX1CYP2D6MEN1ALDH1A1LMNA | |
| SCHEMBL1323180 | 0.74 | EPHX1 (0.39) | EPHX1CYP2D6MEN1ALDH1A1LMNA | |
| SCHEMBL9561971 | 0.74 | EPHX1 (0.44) | EPHX1CYP2D6MEN1ALDH1A1LMNA | |
| SCHEMBL5824287 | 0.74 | EPHX1 (0.44) | EPHX1CYP1A2TSHRSIGMAR1SHBG | |
| SCHEMBL17529723 | 0.74 | EPHX1 (0.44) | EPHX1CYP2D6MEN1ALDH1A1LMNA | |
| SCHEMBL1324554 | 0.74 | EPHX1 (0.39) | EPHX1CYP2D6MEN1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4388459-A | HYPOLIPIDEMIC, ANTIATHEROSCLEROTIC | AMERICAN CYANAMID COMPANY (US) | 1983-06-14 | — | — | US | disclosed |
| US-4259352-A | 4-[Cycloalkyl- or cycloalkenyl-amino(cycloalkyl- or cycloalkenyl-alkenyl)amino]phenyl compounds, useful as hypolipidemic and antiatherosclerotic agents | AMERICAN CYANAMID COMPANY (US) | 1981-03-31 | — | — | US | disclosed |