Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.51 |
| ▸ | AKT2 | P31751 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18151689 | 0.77 | SCN9A (0.40) | CHEK1AKT2PLK4AURKACHUK | |
| SCHEMBL10094635 | 0.77 | AKT2 (0.60) | CHEK1AKT2ROCK2DYRK1ATSHR | |
| SCHEMBL3081398 | 0.73 | CHEK1 (0.37) | CHEK1AKT2PLK4AURKACHUK | |
| SCHEMBL2129650 | 0.71 | AR (0.46) | ROCK2KDRDYRK1ASCN9AKDM4E | |
| SCHEMBL13990881 | 0.71 | AKT2 (0.53) | CHEK1AKT2KDM4ETRPA1GAA | |
| SCHEMBL10094333 | 0.71 | AKT2 (0.53) | CHEK1AKT2ROCK2DYRK1ATRPA1 | |
| SCHEMBL13990747 | 0.71 | AKT2 (0.53) | CHEK1AKT2CDK2DYRK1ATSHR | |
| SCHEMBL3074111 | 0.71 | AR (0.36) | CHEK1AKT2PLK4AURKACHUK | |
| SCHEMBL1132593 | 0.71 | TSHR (0.61) | TSHRKDM4EALDH1A1GALR3GAA | |
| SCHEMBL24478878 | 0.70 | SCN9A (0.38) | CHEK1AKT2PLK4AURKACHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424843-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | Novartis AG (CH) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010125402-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2010-11-04 | — | — | WO | disclosed |