Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11148132 | 0.89 | POLB (0.44) | POLBMEN1KMT2AKDM4EL3MBTL1 | |
| SCHEMBL11149863 | 0.89 | HTT (0.44) | POLBKCNH2KMT2AKDM4EL3MBTL1 | |
| SCHEMBL11156483 | 0.88 | MEN1 (0.40) | POLBKCNH2MEN1KMT2AKDM4E | |
| SCHEMBL11156480 | 0.88 | MEN1 (0.40) | POLBKCNH2MEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL11433492 | 0.88 | POLB (0.43) | POLBMEN1KMT2AKDM4EL3MBTL1 | |
| SCHEMBL11150830 | 0.85 | POLB (0.40) | POLBKCNH2MEN1KMT2AKDM4E | |
| SCHEMBL11148870 | 0.85 | POLB (0.46) | POLBMEN1KMT2AKDM4EL3MBTL1 | |
| SCHEMBL11151675 | 0.82 | MAPT (0.48) | POLBMEN1KMT2AKDM4EMAPT | |
| SCHEMBL11151672 | 0.82 | MAPT (0.48) | POLBMEN1KMT2AKDM4EMAPT | |
| SCHEMBL11152360 | 0.79 | NR1H4 (0.48) | POLBKDM4EL3MBTL1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009683-B1 | BASIC PHENYL ETHERS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE PREPARATION OF THESE ETHERS AND COMPOSITIONS | MERCK PATENT GmbH (DE) | 1983-08-10 | — | — | EP | disclosed |
| EP-0009683-A1 | Basic phenyl ethers, pharmaceutical compositions containing them and the preparation of these ethers and compositions | MERCK PATENT GmbH (DE) | 1980-04-16 | — | — | EP | disclosed |