Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 20/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.55 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21583420 | 0.79 | ADORA2A (0.64) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL11146964 | 0.77 | ADORA2A (0.67) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL21581806 | 0.77 | ADORA2A (0.60) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL11147333 | 0.76 | ADORA2A (0.53) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL21581801 | 0.73 | ADORA2A (1.00) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL11151560 | 0.73 | KDM5A (0.40) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL21581848 | 0.71 | ADORA2A (1.00) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL21583434 | 0.71 | ADORA2A (0.87) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL21581745 | 0.70 | ADORA2A (0.69) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL21583389 | 0.69 | ADORA2A (0.55) | ADORA2AADORA1ADORA2BADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4405780-A | 8-Substituted 7-phenyl-1,2,4,-triazolo[4,3-c]/[2,3-c]pyrimidines-5-amines and amides | G. D. SEARLE & CO. (US) | 1983-09-20 | — | — | US | disclosed |