Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 4/20 | 0.35 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5684775 | 0.82 | TLR4 (0.47) | TLR4PGR | |
| SCHEMBL11062755 | 0.77 | CYP1A2 (0.38) | TLR4 | |
| SCHEMBL296381 | 0.76 | TLR4 (0.35) | TLR4 | |
| SCHEMBL19257857 | 0.70 | CYP2C19 (0.40) | SERPINA6MMP2PGR | |
| SCHEMBL18175548 | 0.70 | CYP2C19 (0.40) | SERPINA6MMP2PGR | |
| SCHEMBL10975419 | 0.70 | — | — | |
| SCHEMBL9924735 | 0.70 | TLR4 (0.42) | TLR4SERPINA6MMP2PGR | |
| SCHEMBL6458057 | 0.69 | TLR4 (0.56) | TLR4 | |
| SCHEMBL6458053 | 0.69 | TLR4 (0.56) | TLR4 | |
| SCHEMBL6453405 | 0.68 | TLR4 (0.64) | TLR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0021587-B1 | SUBSTITUTED DECALINS, THEIR PREPARATION AND USE | BEECHAM GROUP PLC (GB) | 1983-03-02 | — | — | EP | claimed |
| US-4303674-A | TOPICAL ANTIINFLAMMATORY AGENTS | BEECHAM GROUP LIMITED (GB) | 1981-12-01 | — | — | US | claimed |
| EP-0021587-A1 | Substituted decalins, their preparation and use | BEECHAM GROUP PLC (GB) | 1981-01-07 | — | — | EP | claimed |
| EP-0021587-B1 | SUBSTITUTED DECALINS, THEIR PREPARATION AND USE | BEECHAM GROUP PLC (GB) | 1983-03-02 | — | — | EP | disclosed |
| US-4303674-A | TOPICAL ANTIINFLAMMATORY AGENTS | BEECHAM GROUP LIMITED (GB) | 1981-12-01 | — | — | US | disclosed |
| EP-0021587-A1 | Substituted decalins, their preparation and use | BEECHAM GROUP PLC (GB) | 1981-01-07 | — | — | EP | disclosed |