Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 13/20 | 0.48 |
| ▸ | CCND1 | P24385 | 8/20 | 0.48 |
| ▸ | CDK2 | P24941 | 7/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.48 |
| ▸ | CDK1 | P06493 | 3/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.47 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.47 |
| ▸ | CCND2 | P30279 | 3/20 | 0.47 |
| ▸ | CCND3 | P30281 | 3/20 | 0.47 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.47 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.46 |
| ▸ | STK17B | O94768 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1115332 | 0.99 | CDK4 (0.48) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL1115299 | 0.99 | CDK4 (0.48) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL1115542 | 0.77 | CDK4 (0.50) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL1115548 | 0.76 | CDK4 (0.51) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL1115320 | 0.76 | CDK4 (0.51) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL1115244 | 0.74 | CDK4 (0.49) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL1115237 | 0.74 | FLT3 (0.53) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL1643626 | 0.72 | WEE1 (0.47) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL1115407 | 0.71 | CDK4 (0.47) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL3590138 | 0.71 | PDGFRB (0.62) | CDK4CCND1CDK2CCNE1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278973-A1 | GEM-DISUBSTITUTED AND SPIROCYCLIC AMINO PYRIDINES/PYRIMIDINES AS CELL CYCLE INHIBITORS | Amgen Inc. (US) | 2011-02-02 | — | — | EP | claimed |
| WO-2009126584-A1 | GEM-DISUBSTITUTED AND SPIROCYCLIC AMINO PYRIDINES/PYRIMIDINES AS CELL CYCLE INHIBITORS | AMGEN INC. (US) | 2009-10-15 | — | — | WO | claimed |