Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 15/20 | 0.48 |
| ▸ | CCND1 | P24385 | 4/20 | 0.46 |
| ▸ | CDK1 | P06493 | 3/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 1/20 | 0.46 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1115396 | 0.93 | CDK4 (0.53) | CDK4CDK6CCND1CDK1CCNA2 | |
| SCHEMBL1643325 | 0.91 | CDK4 (0.54) | CDK4CDK6CCND1CDK1CCNE2 | |
| SCHEMBL1115178 | 0.86 | CDK4 (0.54) | CDK4CDK6CCND1CDK1CCNE2 | |
| SCHEMBL1115451 | 0.85 | CDK4 (0.55) | CDK4CDK6CCND1CDK1CCNE2 | |
| SCHEMBL12727743 | 0.85 | CDK4 (0.49) | CDK4CDK6CCND1CDK1CCNE2 | |
| SCHEMBL1115270 | 0.85 | CDK4 (0.55) | CDK4CDK6CCND1CDK1CCNE2 | |
| SCHEMBL12727736 | 0.79 | CDK4 (0.51) | CDK4CDK6CCND1CDK1CCNE2 | |
| SCHEMBL12727738 | 0.78 | LRRK2 (0.52) | CDK4CDK6CCND1CDK1CCNE2 | |
| SCHEMBL1115258 | 0.77 | CDK4 (0.51) | CDK4CDK6CCND1CDK1CCNA2 | |
| SCHEMBL12727721 | 0.77 | CDK4 (0.51) | CDK4CDK6CCND1CDK1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278973-A1 | GEM-DISUBSTITUTED AND SPIROCYCLIC AMINO PYRIDINES/PYRIMIDINES AS CELL CYCLE INHIBITORS | Amgen Inc. (US) | 2011-02-02 | — | — | EP | claimed |
| WO-2009126584-A1 | GEM-DISUBSTITUTED AND SPIROCYCLIC AMINO PYRIDINES/PYRIMIDINES AS CELL CYCLE INHIBITORS | AMGEN INC. (US) | 2009-10-15 | — | — | WO | claimed |