Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.35 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.35 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11497264 | 0.88 | KDM4E (0.41) | TP53KDM4EALDH1A1CYP3A4TSHR | |
| SCHEMBL11152691 | 0.81 | TP53 (0.36) | TP53KDM4EALDH1A1CYP3A4CNR2 | |
| SCHEMBL11157008 | 0.80 | MEN1 (0.43) | TP53KDM4EALDH1A1CYP3A4TSHR | |
| SCHEMBL11158786 | 0.78 | CNR2 (0.45) | TP53KDM4ECA2ALDH1A1CYP3A4 | |
| SCHEMBL11159265 | 0.77 | CNR2 (0.41) | TP53KDM4EALDH1A1CNR2TSHR | |
| SCHEMBL11155148 | 0.75 | TP53 (0.41) | TP53KDM4EALDH1A1CYP3A4TSHR | |
| SCHEMBL11155145 | 0.75 | MEN1 (0.41) | TP53KDM4EALDH1A1CYP3A4CNR2 | |
| SCHEMBL11153674 | 0.75 | CNR2 (0.47) | CNR2CNR1 | |
| SCHEMBL19347267 | 0.74 | CNR2 (0.46) | TP53KDM4ECNR2TSHRMEN1 | |
| SCHEMBL11153091 | 0.74 | CNR2 (0.45) | TP53KDM4EALDH1A1CNR2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0022634-B1 | ACYLATED INDOLE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS AND DRUGS COMPRISING THEM | TEIJIN LIMITED (JP) | 1983-04-06 | — | — | EP | disclosed |
| EP-0022634-A1 | Acylated indole derivatives, processes for their preparation and pharmaceutical compositions and drugs comprising them | TEIJIN LIMITED (JP) | 1981-01-21 | — | — | EP | disclosed |