Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 14/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.48 |
| ▸ | PDE4A | P27815 | 2/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11175176 | 0.90 | PDE3B (0.66) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11162328 | 0.89 | PDE3B (0.65) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11162969 | 0.89 | PDE3B (0.67) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11171310 | 0.87 | PDE3B (0.61) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11167091 | 0.86 | PDE3B (0.60) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11165831 | 0.85 | PDE3B (0.61) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11165047 | 0.84 | PDE3B (0.77) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10473610 | 0.84 | PDE3B (0.69) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11571863 | 0.81 | PDE3B (0.71) | PDE3BPDE3AMAPTTNNC1GPR119 | |
| SCHEMBL16157007 | 0.81 | PDE3B (0.71) | PDE3BPDE3AMAPTTNNC1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4415571-A | HYPOTENSIVE AGENTS; THROMBOSIS; ANTICOAGULANTS; CARDIOVASCULAR DISORDDERS | BASF AKTIENGESELLSCHAFT (DE) | 1983-11-15 | — | — | US | disclosed |
| EP-0042513-A1 | Dihydropyridazinones, processes for their preparation and pharmaceutical compositions containing these compounds | BASF Aktiengesellschaft (DE) | 1981-12-30 | — | — | EP | disclosed |