Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 9/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9591070 | 0.90 | HPGD (0.59) | NPC1RAB9AHPGDCYP1A2CYP2D6 | |
| SCHEMBL11177782 | 0.88 | HPGD (0.60) | NPC1RAB9AHPGDCYP1A2CYP2D6 | |
| SCHEMBL6697261 | 0.83 | NPC1 (0.58) | NPC1RAB9AHPGDCYP1A2CYP2D6 | |
| SCHEMBL3111473 | 0.83 | NPC1 (0.58) | NPC1RAB9AHPGDCYP1A2CYP2D6 | |
| SCHEMBL317815 | 0.83 | NPC1 (0.65) | NPC1RAB9AHPGDCYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL6701190 | 0.82 | NPC1 (0.57) | NPC1RAB9AHPGDCYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL6441990 | 0.82 | NPC1 (0.57) | NPC1RAB9AHPGDCYP1A2CYP2D6 | |
| SCHEMBL3288225 | 0.80 | NPC1 (0.63) | NPC1RAB9AHPGDCYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL6698771 | 0.80 | NPC1 (0.54) | NPC1RAB9AHPGDCYP1A2CYP2D6 | |
| SCHEMBL19226216 | 0.79 | NPC1 (0.46) | NPC1RAB9AHPGDCYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0018735-B1 | 1,8-NAPHTHYRIDINE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-07-27 | — | — | EP | disclosed |
| US-4350817-A | 4-Cl, Br or I-3-Carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-21 | — | — | US | disclosed |
| US-4347362-A | HYPOTENSIVE | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-08-31 | — | — | US | disclosed |
| US-4324893-A | 4-Amino-3-carboxy or cyano-1,2-dihydro-2-oxo-1,8-naphthyridine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-04-13 | — | — | US | disclosed |
| WO-1980002287-A1 | 1,8-NAPHTHYRIDINE DERIVATIVES | AMERICAN HOME PROD (US) | 1980-10-30 | — | — | WO | disclosed |