Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 12/20 | 0.62 |
| ▸ | CACNA1D | Q01668 | 12/20 | 0.62 |
| ▸ | CACNA1S | Q13698 | 12/20 | 0.62 |
| ▸ | CACNA1C | Q13936 | 12/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11163615 | 0.93 | CACNA1F (0.56) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL11166086 | 0.93 | MEN1 (0.57) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL11171133 | 0.92 | CACNA1F (0.60) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL11158896 | 0.91 | CACNA1C (0.59) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL11375871 | 0.90 | CACNA1F (0.53) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL11175854 | 0.90 | MEN1 (0.55) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL11176099 | 0.90 | CACNA1F (0.55) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL6425850 | 0.88 | MEN1 (0.67) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL11371616 | 0.88 | CACNA1F (0.66) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 | |
| SCHEMBL11365640 | 0.88 | CACNA1C (0.53) | CACNA1FCACNA1DCACNA1SCACNA1CADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0039863-B1 | 1,4-DIHYDROPYRIDINES WITH DIFFERENT SUBSTITUENTS IN POSITIONS 2 AND 6, PROCESSES FOR THEIR PREPARATION AND THEIR USE IN MEDICINES | BAYER AG (DE) | 1983-12-28 | — | — | EP | disclosed |
| EP-0039863-A1 | 1,4-Dihydropyridines with different substituents in positions 2 and 6, processes for their preparation and their use in medicines | BAYER AG (DE) | 1981-11-18 | — | — | EP | disclosed |