Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | BPTF | Q12830 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11166349 | 0.98 | CYP1A2 (0.45) | CYP1A2BPTFHTTSMN1; SMN2CHRM4 | |
| SCHEMBL11163911 | 0.86 | KDM4E (0.42) | CYP1A2BPTFSMN1; SMN2NPC1RAB9A | |
| Mopidralazine SCHEMBL2109925 | 0.85 | KDM4E (0.53) | BPTFHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL11162271 | 0.85 | BPTF (0.60) | CYP1A2BPTFHTTKDM4E | |
| SCHEMBL11167255 | 0.85 | BPTF (0.41) | CYP1A2BPTFHTTSMN1; SMN2CNR2 | |
| SCHEMBL26739775 | 0.78 | CYP1A2 (0.55) | CYP1A2BPTFHTTSMN1; SMN2CHRM4 | |
| SCHEMBL18912708 | 0.76 | CYP1A2 (0.52) | CYP1A2BPTFHTTSMN1; SMN2CHRM4 | |
| SCHEMBL14503215 | 0.75 | CYP1A2 (0.75) | CYP1A2BPTFHTTSMN1; SMN2CHRM4 | |
| SCHEMBL11260280 | 0.75 | CYP1A2 (0.55) | CYP1A2BPTFCHRM4NPC1RAB9A | |
| SCHEMBL11164123 | 0.75 | CYP1A2 (0.55) | CYP1A2BPTFCHRM4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009655-B1 | 6-AMINO SUBSTITUTED N-PYRROLYL-3-PYRIDAZINE AMINES, THEIR PREPARATION, AND PHARMACEUTICALLY ANTIHYPERTENSIVE COMPOSITIONS CONTAINING THEM | GRUPPO LEPETIT S.P.A. (IT) | 1983-05-11 | — | — | EP | disclosed |
| US-4247551-A | N-Pyrrolyl-pyridazineamines and their use as antihypertensive agents | GRUPPO LEPETIT S.P.A. (IT) | 1981-01-27 | — | — | US | disclosed |
| EP-0009655-A1 | 6-Amino substituted N-pyrrolyl-3-pyridazine amines, their preparation, and pharmaceutically antihypertensive compositions containing them | GRUPPO LEPETIT S.P.A. (IT) | 1980-04-16 | — | — | EP | disclosed |