Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.63 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.56 |
| ▸ | PDE5A | O76074 | 3/20 | 0.49 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.49 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11188667 | 0.85 | MRGPRX4 (0.78) | MRGPRX4PDE5ACYSLTR1GPBAR1KCNH2 | |
| SCHEMBL22480814 | 0.82 | MRGPRX4 (0.68) | MRGPRX4PDE5ACYSLTR1GPBAR1KCNH2 | |
| SCHEMBL22481085 | 0.77 | MRGPRX4 (1.00) | MRGPRX4NR4A2PDE5AKCNH2 | |
| SCHEMBL3564550 | 0.77 | MRGPRX4 (0.74) | MRGPRX4PDE5AGPBAR1KCNH2 | |
| SCHEMBL27703908 | 0.77 | MRGPRX4 (0.74) | MRGPRX4PDE5AGPBAR1KCNH2 | |
| SCHEMBL12752870 | 0.77 | GRM5 (0.56) | GRM5 | |
| SCHEMBL15932121 | 0.77 | NR4A2 (0.51) | MRGPRX4NR4A2 | |
| SCHEMBL4500448 | 0.77 | NR4A2 (0.61) | MRGPRX4NR4A2 | |
| SCHEMBL22480681 | 0.76 | MRGPRX4 (0.65) | MRGPRX4PDE5A | |
| SCHEMBL11375748 | 0.76 | MRGPRX4 (0.59) | MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4390543-A | Substituted pyridine methyl esters of 2-isopropyl-2-(4-chlorophenyl) acetic acid and their use as insecticides | MALHOTRA SUDARSHAN K | 1983-06-28 | — | — | US | disclosed |
| US-4281133-A | INSECTICIDES | THE DOW CHEMICAL COMPANY (US) | 1981-07-28 | — | — | US | disclosed |
| US-4262001-A | MITICIDES, PARASITICIDES, LARVICIDES | THE DOW CHEMICAL COMPANY (US) | 1981-04-14 | — | — | US | disclosed |
| US-4258048-A | Substituted pyridine methyl esters of tetramethyl cyclopropane carboxylic acids and their use as insecticides | THE DOW CHEMICAL COMPANY (US) | 1981-03-24 | — | — | US | disclosed |
| US-4256893-A | INSECTICIDES | THE DOW CHEMICAL COMPANY (US) | 1981-03-17 | — | — | US | disclosed |
| US-4228172-A | Substituted pyridine methyl esters of 2-isopropyl-2-(4-chlorophenyl)acetic acid and their use as insecticides | THE DOW CHEMICAL COMPANY (US) | 1980-10-14 | — | — | US | disclosed |
| US-4221799-A | MITICIDES | THE DOW CHEMICAL (US) | 1980-09-09 | — | — | US | disclosed |
| US-4163787-A | Substituted pyridine methyl esters of cyclopropane carboxylic acids and their use as insecticides | THE DOW CHEMICAL COMPANY (US) | 1979-08-07 | — | — | US | disclosed |