Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11183121 | 0.83 | CYP2C9 (0.50) | TSHRKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL11183124 | 0.83 | CYP2C9 (0.50) | TSHRKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL11175953 | 0.82 | TSHR (0.69) | TSHRCYP3A4KMT2AMEN1ALDH1A1 | |
| SCHEMBL11876015 | 0.80 | APEX1 (0.41) | TSHRKMT2AMEN1MAPTGAA | |
| SCHEMBL11876019 | 0.80 | APEX1 (0.41) | TSHRKMT2AMEN1MAPTGAA | |
| SCHEMBL11175134 | 0.80 | TSHR (0.66) | TSHRCYP3A4KMT2AMEN1ALDH1A1 | |
| SCHEMBL11173323 | 0.80 | TSHR (0.66) | TSHRCYP3A4KMT2AMEN1ALDH1A1 | |
| SCHEMBL11167770 | 0.79 | TSHR (0.54) | TSHRCYP3A4KMT2AALDH1A1MAPT | |
| SCHEMBL11165778 | 0.78 | TSHR (0.64) | TSHRCYP3A4KMT2AMEN1ALDH1A1 | |
| SCHEMBL1001249 | 0.77 | APEX1 (0.73) | TSHRCYP3A4KMT2AALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4377521-A | ANTILIPEMIC | PFIZER INC. (US) | 1983-03-22 | — | — | US | disclosed |
| US-4138399-A | Sulfamylbenzoic acid | PFIZER INC. (US) | 1979-02-06 | — | — | US | disclosed |
| US-4124590-A | CARDIOVASCULAR DISORDERS, ANTILIPEMIC AGENTS | PFIZER INC. (US) | 1978-11-07 | — | — | US | disclosed |
| US-3992441-A | ANTILIPEMIC | PFIZER INC. (US) | 1976-11-16 | — | — | US | disclosed |