Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 13/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | HRH2 | P25021 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | ATP4A | P20648 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ATP4B | P51164 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11179026 | 0.88 | HRH4 (0.51) | HRH4HRH3CYP3A4CYP2D6LMNA | |
| SCHEMBL11190072 | 0.82 | HRH4 (0.54) | HRH4HRH3CYP3A4CYP2D6LMNA | |
| SCHEMBL11178131 | 0.80 | HRH4 (0.33) | HRH4HRH3CYP3A4CYP2D6LMNA | |
| SCHEMBL11178134 | 0.80 | HRH4 (0.33) | HRH4HRH3CYP3A4CYP2D6LMNA | |
| SCHEMBL7653936 | 0.78 | CYP3A4 (0.67) | HRH4HRH3CYP3A4CYP2D6LMNA | |
| SCHEMBL10413112 | 0.78 | CYP3A4 (0.67) | HRH4HRH3CYP3A4CYP2D6LMNA | |
| SCHEMBL11180142 | 0.77 | HRH4 (0.40) | HRH4HRH3CYP3A4CYP2D6LMNA | |
| SCHEMBL11173793 | 0.75 | HRH4 (0.40) | HRH4HRH3CYP3A4CYP2D6LMNA | |
| SCHEMBL11179536 | 0.73 | HRH4 (0.41) | HRH4HRH3CYP3A4CYP2D6LMNA | |
| SCHEMBL11174311 | 0.73 | HRH4 (0.38) | HRH4HRH3CYP3A4CYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4413130-A | INHIBITORS OF HISTAMINE H-2 RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-11-01 | — | — | US | disclosed |
| US-4338328-A | HISTAMINE H-2 RECEPTOR ANTAGONISTS | SMITHKLINE & FRENCH LABORATORIES LIMITED (GB) | 1982-07-06 | — | — | US | disclosed |
| US-4255425-A | ANTIHESTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1981-03-10 | — | — | US | disclosed |
| US-4140783-A | INHIBITORS OF HISTAMINE H-2 RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1979-02-20 | — | — | US | disclosed |
| US-4056620-A | INHIBITION OF HISTAMINE H-2 RECEPTORS | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1977-11-01 | — | — | US | disclosed |