Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.38 |
| ▸ | ADCY6 | O43306 | 2/20 | 0.42 |
| ▸ | ADCY3 | O60266 | 2/20 | 0.42 |
| ▸ | ADCY9 | O60503 | 2/20 | 0.42 |
| ▸ | ADCY5 | O95622 | 2/20 | 0.42 |
| ▸ | ADCY8 | P40145 | 2/20 | 0.42 |
| ▸ | ADCY7 | P51828 | 2/20 | 0.42 |
| ▸ | ADCY2 | Q08462 | 2/20 | 0.42 |
| ▸ | ADCY1 | Q08828 | 2/20 | 0.42 |
| ▸ | ADCY4 | Q8NFM4 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 10/20 | 0.40 |
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 2/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11159318 | 0.80 | DRD1 (0.47) | DRD1DRD2KDM4EMAPK1BLM | |
| SCHEMBL10471907 | 0.78 | DRD1 (0.44) | DRD1DRD2KDM4EMAPK1BLM | |
| Bromide SCHEMBL11156560 | 0.75 | MEN1 (0.42) | DRD1DRD2KDM4EBLMGFER | |
| Bromide SCHEMBL11159081 | 0.73 | KDM4E (0.48) | DRD1DRD2KDM4EBLMGFER | |
| Bromide SCHEMBL11215989 | 0.73 | HRH3 (0.41) | DRD1DRD2KDM4EBLMGFER | |
| Bromide SCHEMBL11156979 | 0.73 | NPC1 (0.41) | — | |
| Bromide SCHEMBL11156982 | 0.71 | DRD1 (0.36) | DRD1DRD2KDM4EBLMGFER | |
| Bromide SCHEMBL11165457 | 0.71 | KDM4E (0.34) | DRD1DRD2KDM4EBLMGFER | |
| Bromide SCHEMBL11546764 | 0.71 | DRD1 (0.43) | ADCY6ADCY3ADCY9ADCY5ADCY8 | |
| SCHEMBL10701614 | 0.69 | HTR2C (0.55) | DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0080012-A1 | 6-Chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its acid addition salts and its use as an intermediate | SMITHKLINE BECKMAN CORPORATION (US) | 1983-06-01 | — | — | EP | disclosed |
| EP-0007070-B1 | 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS HAVING DOPAMINE RECEPTOR BLOCKING ACTIVITY | SMITHKLINE BECKMAN CORPORATION (US) | 1983-01-19 | — | — | EP | disclosed |
| US-4265890-A | ANTIPSYCHOTIC, ANTIEMETICS | SMITHKLINE CORPORATION (US) | 1981-05-05 | — | — | US | disclosed |
| EP-0007070-A1 | 2,3,4,5-Tetrahydro-1H-3-Benzazepines, process for their production and pharmaceutical compositions having dopamine receptor blocking activity | SMITHKLINE BECKMAN CORPORATION (US) | 1980-01-23 | — | — | EP | disclosed |