Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11257600 | 0.87 | ACE (0.53) | ACEALDH1A1HPGDPOLBKMT2A | |
| SCHEMBL11219632 | 0.82 | ACE (0.48) | ACEALDH1A1HPGDPOLBHSD17B10 | |
| SCHEMBL11252420 | 0.79 | ACE (0.55) | ACEALDH1A1HPGDPOLBGAA | |
| SCHEMBL11067695 | 0.73 | KMT2A (0.53) | ACEALDH1A1HPGDPOLBHSD17B10 | |
| SCHEMBL11195316 | 0.72 | ACE (0.55) | ACEALDH1A1HPGDPOLBHSD17B10 | |
| SCHEMBL11261862 | 0.71 | ACE (0.60) | ACEALDH1A1HPGDPOLBKMT2A | |
| SCHEMBL10944233 | 0.71 | ACE (0.47) | ACEALDH1A1HPGDPOLBHSD17B10 | |
| SCHEMBL11179426 | 0.71 | ACE (0.64) | ACEALDH1A1HPGDPOLBHSD17B10 | |
| SCHEMBL683643 | 0.71 | ACE (0.64) | ACEALDH1A1HPGDPOLBHSD17B10 | |
| SCHEMBL11221414 | 0.70 | ACE (0.55) | ACEALDH1A1HPGDPOLBGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4410542-A | HYPOTENSIVE AGENTS, PYRROLINE-1,2-DICARBOXYLIC ACID DERIVATIVES | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| US-4347371-A | HYPERTENSIVE AGENTS; ANTIDIABETIC AGENTS; VISION DEFECTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1982-08-31 | — | — | US | disclosed |