SCHEMBL1119793

SCHEMBL1119793

CC(C)C[Si](C)(C)OS(=O)(=O)C(F)(F)F

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL630910 0.82
SCHEMBL2453134 0.82
SCHEMBL14689167 0.77
SCHEMBL538604 0.77
SCHEMBL14981496 0.72
SCHEMBL537785 0.72
SCHEMBL5960752 0.72
SCHEMBL14777968 0.71 CA1 (0.32)
SCHEMBL28527 0.71 CA1 (0.32)
SCHEMBL630962 0.71 CA1 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4139293-A1 RSV INHIBITING 3-SUBSTITUTED QUINOLINE AND CINNOLINE DERIVATIVES Janssen Sciences Ireland Unlimited Company (IE) 2023-03-01 EP disclosed
US-20220340535-A1 MCL-1 INHIBITORS GILEAD SCIENCES, INC. 2022-10-27 US disclosed
WO-2021214136-A1 RSV INHIBITING 3-SUBSTITUTED QUINOLINE AND CINNOLINE DERIVATIVES Janssen Sciences Ireland Unlimited Company (IE) 2021-10-28 WO disclosed
EP-3447045-B9 1-(1-HYDROXY-2,3-DIHYDRO-1H-INDEN-5-YL)-UREA DERIVATIVES AND RELATED COMPOUNDS KCNQ 2-5 CHANNEL ACTIVATORS FOR TREATING DYSURIA ONO PHARMACEUTICAL CO (JP) 2021-07-21 EP disclosed
EP-3447045-B1 1-(1-HYDROXY-2,3-DIHYDRO-1H-INDEN-5-YL)-UREA DERIVATIVES AND RELATED COMPOUNDS KCNQ 2-5 CHANNEL ACTIVATORS FOR TREATING DYSURIA ONO PHARMACEUTICAL CO (JP) 2021-03-03 EP disclosed
US-20190127320-A1 KCNQ2-5 CHANNEL ACTIVATOR ONO PHARMACEUTICAL CO., LTD. (JP) 2019-05-02 US disclosed
EP-2571859-A2 HYDROXYBUPROPION ANALOGUES FOR TREATING DRUG DEPENDENCE Research Triangle Institute (US) 2013-03-27 EP disclosed
EP-2512243-A1 QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS Merck Sharp & Dohme Corp. (US) 2012-10-24 EP disclosed
WO-2012125871-A2 ACONITINE COMPOUNDS, COMPOSITIONS, USES, AND PREPARATION THEREOF THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2012-09-20 WO disclosed
WO-2011146821-A2 1 - PHENYLMORPHOLINE DERIVATIVES AS HYDROXYBUPROPION ANALOGUES FOR TREATING DRUG DEPENDENCE RESEARCH TRIANGLE INSTITUTE (US) 2011-11-24 WO disclosed
WO-2011084368-A1 QUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS MERCK SHARP & DOHME CORP. (US) 2011-07-14 WO disclosed
EP-2280987-A2 TRITERPENE SAPONINS, METHODS OF SYNTHESIS, AND USES THEREOF Sloan Kettering Institute For Cancer Research (US) 2011-02-09 EP disclosed
WO-2009126737-A2 TRITERPENE SAPONINS, METHODS OF SYNTHESIS, AND USES THEREOF SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 2009-10-15 WO disclosed