Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11164525 | 0.89 | MAPT (0.46) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL11164561 | 0.89 | MAPT (0.46) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL11190019 | 0.88 | MAPT (0.45) | NPC1RAB9AMAPTLMNADNMT3A | |
| SCHEMBL11191065 | 0.85 | MAPT (0.54) | NPC1RAB9AKMT2AMAPTLMNA | |
| SCHEMBL11193046 | 0.84 | MAPT (0.53) | NPC1RAB9AMAPTLMNAKDM4E | |
| SCHEMBL11441498 | 0.83 | MCHR1 (0.56) | NPC1RAB9AMAPTLMNADNMT3A | |
| SCHEMBL11194495 | 0.83 | EGFR (0.53) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL11165965 | 0.83 | MCHR1 (0.55) | MAPTLMNAMCHR1CYP2D6POLB | |
| SCHEMBL10356773 | 0.83 | MCHR1 (0.55) | MAPTLMNAMCHR1CYP2D6POLB | |
| SCHEMBL11165531 | 0.83 | MCHR1 (0.55) | MAPTLMNAMCHR1CYP2D6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0023569-B1 | DERIVATIVES OF CARBOXYLIC ACIDS, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1983-06-22 | — | — | EP | disclosed |
| EP-0023569-A1 | Derivatives of carboxylic acids, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1981-02-11 | — | — | EP | disclosed |