Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 9/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11202444 | 0.98 | HPGD (0.54) | HPGDALDH1A1TSHRPOLBHSP90AA1 | |
| SCHEMBL10720608 | 0.74 | TSHR (0.69) | HPGDALDH1A1TSHRPOLBMEN1 | |
| SCHEMBL28159515 | 0.71 | HPGD (0.59) | HPGDALDH1A1USP2KDM4E | |
| SCHEMBL29944401 | 0.70 | HPGD (0.62) | HPGDALDH1A1TSHRPOLBMEN1 | |
| SCHEMBL31017961 | 0.70 | HPGD (0.47) | HPGDALDH1A1POLBMEN1KMT2A | |
| SCHEMBL14703243 | 0.70 | HPGD (0.69) | HPGDALDH1A1TSHRPOLBHSP90AA1 | |
| SCHEMBL10519302 | 0.69 | HTT (0.57) | HPGDALDH1A1TSHRPOLBMEN1 | |
| SCHEMBL10721733 | 0.69 | HPGD (0.95) | HPGDALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL1008405 | 0.68 | MAPT (0.65) | HPGDALDH1A1TSHRPOLBMEN1 | |
| SCHEMBL30203951 | 0.68 | MAPT (0.65) | HPGDALDH1A1TSHRPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4414220-A | HUPOGLYCEMIC, ANTIDIABETIC | PFIZER INC. (US) | 1983-11-08 | — | — | US | disclosed |
| US-4333932-A | DIHYDROISOINDOLES, HYPOGLYCEMIC, ANTIDIABETIC | PFIZER INC. (US) | 1982-06-08 | — | — | US | disclosed |
| EP-0010896-B1 | ORGANIC DIAMINE COMPOUNDS FOR USE AS ORAL HYPOGLYCEMIC AGENTS AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER INC. (US) | 1981-12-30 | — | — | EP | disclosed |
| US-4220650-A | HYPOGLYCEMIC | PFIZER INC. (US) | 1980-09-02 | — | — | US | disclosed |
| EP-0010896-A1 | Organic diamine compounds for use as oral hypoglycemic agents and pharmaceutical compositions thereof | PFIZER INC. (US) | 1980-05-14 | — | — | EP | disclosed |