Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 8/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.46 |
| ▸ | PIM1 | P11309 | 4/20 | 0.37 |
| ▸ | GSK3B | P49841 | 4/20 | 0.37 |
| ▸ | FBP1 | P09467 | 2/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | CDK7 | P50613 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL457717 | 0.85 | PIK3CD (0.68) | PIK3CDPIK3CGPIK3CAPIK3CBPIM1 | |
| SCHEMBL1120285 | 0.81 | PIK3CD (0.48) | PIK3CDPIK3CGPIK3CAPIK3CBPIM1 | |
| SCHEMBL1772497 | 0.78 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3CAPIK3CBPIM1 | |
| SCHEMBL1959907 | 0.78 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3CAPIK3CBPIM1 | |
| SCHEMBL1959680 | 0.76 | PIK3CD (0.62) | PIK3CDPIK3CGPIK3CAPIK3CBPIM1 | |
| SCHEMBL1118820 | 0.75 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3CAPIK3CBPIM1 | |
| SCHEMBL2056099 | 0.75 | PIK3CD (0.63) | PIK3CDPIK3CGPIK3CAPIK3CBPIM1 | |
| SCHEMBL1772173 | 0.75 | PIK3CD (0.64) | PIK3CDPIK3CGPIK3CAPIK3CBPIM1 | |
| SCHEMBL1957355 | 0.73 | PIK3CD (0.62) | PIK3CDPIK3CGPIK3CAPIK3CBPIM1 | |
| SCHEMBL1959511 | 0.73 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3CAPIK3CBPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280946-A1 | 4-CARBOXAMIDE INDAZOLE DERIVATIVES USEFUL AS INHIBITORS OF P13-KINASES | Glaxo Group Limited (GB) | 2011-02-09 | — | — | EP | disclosed |