Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 7/20 | 0.39 |
| ▸ | BCHE | P06276 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | CCR3 | P51677 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349857 | 0.67 | PDE3B (0.45) | PDE3BPDE3ANPC1HPGDRAB9A | |
| SCHEMBL29766889 | 0.67 | NPC1 (0.41) | PDE3BPDE3ANPC1HPGDRAB9A | |
| SCHEMBL5188925 | 0.67 | NPC1 (0.41) | PDE3BPDE3ANPC1HPGDRAB9A | |
| SCHEMBL10767417 | 0.67 | HPGD (0.41) | PDE3BPDE3ANPC1HPGDRAB9A | |
| SCHEMBL10376168 | 0.66 | PDE3B (0.55) | PDE3BPDE3ASIGMAR1ACHEBCHE | |
| Hydrochloric Acid SCHEMBL30528596 | 0.66 | NPC1 (0.44) | PDE3BPDE3ANPC1HPGDRAB9A | |
| SCHEMBL6738853 | 0.66 | NPC1 (0.40) | PDE3BPDE3ANPC1HPGDRAB9A | |
| SCHEMBL11497896 | 0.64 | NPC1 (0.42) | PDE3BPDE3ANPC1HPGDRAB9A | |
| Hydrochloric Acid SCHEMBL11522942 | 0.64 | PDE3B (0.54) | PDE3BPDE3ASIGMAR1ACHEBCHE | |
| SCHEMBL1570768 | 0.64 | PDE3B (1.00) | PDE3BPDE3AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4372956-A | CARDIOTONIC AGENTS, VASODILATION | SANDOZ LTD. (CH) | 1983-02-08 | — | — | US | disclosed |
| EP-0029559-A2 | 5,10-dihydroimidazo(2,1-b)quinazolines, their production and pharmaceutical compositions containing them | SANDOZ AG (CH) | 1981-06-03 | — | — | EP | disclosed |